4 CONTRAINDICATIONS

This eye damage is called non-arteritic anterior ischemic optic neuropathy (NAION).

In case of emergency/overdose

Your care team can check for harmful interactions and adjust your medications if needed. Don't take nitrate medications, such as nitroglycerin (Nitrostat), with sildenafil (Revatio). This can make your blood pressure drop to dangerously low levels. Get medical help right away if you have sudden changes in vision or hearing while taking sildenafil (Revatio). Also get emergency help if you have an erection that lasts for more than 4 hours or is very painful.

Sildenafil side effects

These problems can be serious and should get checked out. More tips for the 10 mg/mL oral suspension of sildenafil (Revatio): The pharmacy will prepare the oral suspension when you pick up the medication. They'll also give you a dosing cup, spoon, or oral syringe to help you measure out your dose. Before taking a dose, shake the bottle well for at least 10 seconds. Use a medication dosing cup, spoon, or oral syringe to measure out your dose.

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They might not be accurate, so you might take the wrong dose. There are two options to store the oral suspension. You can keep it at room temperature (up to 86ºF). Or, you can put it in the refrigerator (though be sure not to let it freeze). Once you get the oral suspension from the pharmacy, the medication is good for 60 days. It happens when there's poor blood flow to the nerves in the eye. Symptoms include sudden loss of vision in one eye, eye pain, and headache. It might lead to permanent vision loss if not treated. Before you start sildenafil (Revatio), tell your prescriber about your full medical history. This medication isn't recommended for people with an eye problem called retinitis pigmentosa. The risk of this eye damage might also be higher if an eye specialist has told you that you have a "crowded" optic disc.

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If you have sudden vision changes or lose vision in one or both eyes while taking sildenafil (Revatio), go to the emergency room or call an eye specialist right away. They can check out what's going on.

5.1 Mortality with Pediatric Use

Sildenafil (Revatio) isn't recommended if you have pulmonary vascular occlusive disease (PVOD). This is a rare condition that affects the blood flow between your lungs and heart. Sildenafil (Revatio) sildenafil pricing hasn't been studied in people with PVOD. But it's possible that it can make this condition worse. Tell your care team if you have any shortness of breath, a cough that doesn't go away, tiredness, or chest pain.

How does sildenafil work (mechanism of action)?

These could be signs of fluid buildup in your lungs, and your care team should check you for PVOD. Risk factors: PAH due to connective tissue disease Also taking the blood thinner called warfarin This is more likely to happen if you take the blood thinner warfarin. Tell your care team if you start getting nosebleeds often. And get medical attention if you have a nosebleed that you can't stop. Risk factors: History of eye problems, including a "crowded" optic disc Although rare, reports of eye damage might be linked to taking PDE5 inhibitors like sildenafil (Revatio). Some people who took sildenafil (Revatio) reported hearing loss. This can sometimes happen with ringing in the ears (tinnitus) and dizziness.

Precaution/Contraindication	Description	Notes
Nitrate use	Do not take with nitrates for chest pain	Risk of severe hypotension
Heart conditions	Consult a doctor if you have cardiovascular issues	Risk of adverse cardiovascular events
Liver or kidney impairment	Reduced dosing may be necessary	Altered drug metabolism
Drug interactions	Combine with caution; may interact with other meds	Always consult a healthcare provider

It isn't clear whether these effects are related to the medication or to other factors. Let your prescriber know if you notice changes in your hearing in one or both ears while taking sildenafil (Revatio). Don't take sildenafil (Revatio) with other PDE5 inhibitors. This includes sildenafil (Viagra) for erectile dysfunction (ED). Taking more than one PDE5 inhibitor at the same time isn't recommended.

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Taking them too close together can put you at risk of side effects, like headache and low blood pressure. You can take sildenafil (Revatio) with or without food. Don't break, crush, or chew the tablet. If you can't swallow them well, talk to your prescriber. They might be able to switch you to the oral suspension of medication.

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

Sildenafil (Revatio) can make your blood pressure drop and make you feel dizzy for a short time after taking it. Then when you feel better, stand up slowly and hold onto something strong to help you up. If dizziness doesn't go away or if you have a racing heart, let your care team know. Don't change your dose or stop taking sildenafil (Revatio) unless your prescriber tells you to. This is important even if you start to feel better.

Dosage forms

Stopping too soon can cause your symptoms to come back and can worsen your PAH. Tell your healthcare team about all the medications you take or plan to take. This includes prescriptions, over-the-counter medications, vitamins, and supplements. Sildenafil (Revatio) can interact with many medications. Some are for blood pressure, enlarged prostate, or erectile dysfunction. It might raise your risk of side effects, like very low blood pressure, dizziness, headaches, and flushing.

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The pharmacist usually writes the expiration date on the label on the bottle. Throw the medication away after this date, even if there's still medication left over. Sildenafil (Revatio) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

What should I do if I accidentally use too much sildenafil?

Risk factors: Certain heart problems Low fluids in the body (dehydration) Low blood pressure at rest Also taking erectile dysfunction medications Also taking blood pressure medications Also taking nitrates like nitroglycerin Sildenafil (Revatio) can cause your blood pressure to drop. It can make you feel dizzy, tired, or lightheaded. This side effect is usually mild and doesn't last long. Tell your prescriber and pharmacist about all the medications you take. You're at risk of having this side effect if you also take other medications that lower blood pressure.

What should I do if I miss a dose of sildenafil?

You can't take sildenafil (Revatio) if you also take nitrates like nitroglycerin. This is because of the risk of a severe drop in blood pressure. After you take sildenafil (Revatio), sit down for the first few minutes to help prevent dizziness. Get emergency help if you feel like you might pass out, feel confused, have a fast heartbeat, or have chest pain. These can be serious signs of very low blood pressure. Risk factors: Medical conditions that affect the penis Sickle cell anemia Multiple myeloma Leukemia Although rare, some people have had an erection that lasted more than 4 hours after taking a PDE5 inhibitor like sildenafil (Revatio). This can be very painful and might cause permanent damage to your penis if not treated in time. Get medical help right away if you have an erection that lasts longer than 4 hours or if you feel pain during an erection. Adults: The typical dose is 20 mg by mouth three times per day. Your prescriber can adjust the dose based on how well it's working and if you have side effects. The maximum dose is 80 mg by mouth three times per day. Children ages 1 year and older: The dose depends on your child's weight. Weight of 44 lbs or less: The typical dose is 10 mg by mouth three times per day. Weight of 44 to 99 lbs: The typical dose is 20 mg by mouth three times per day. Weight of 99 lbs or more: The typical dose is 20 mg by mouth three times per day. If needed, the prescriber might adjust the dose. The maximum dose is 40 mg by mouth three times per day. Sildenafil (Revatio) is also available as an injection that's given into a vein for people in the hospital who can't take it by mouth. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

• Sildenafil tablets are often stored in their original packaging to avoid contamination.
• Use only the amount prescribed; more does not mean better results.
• Sildenafil helps improve erectile function but doesn’t increase libido.
• The tablets are designed for rapid and effective absorption.
• Always inform your doctor about existing health conditions before use.
• Some brands of sildenafil are marketed as "white tablets" for easy recognition.
• The medication can cause a mild increase in blood flow to other body parts.
• Avoid caffeine or heavy meals before taking sildenafil for better results.
• The safety and efficacy of sildenafil are supported by numerous clinical trials.
• Never take expired sildenafil tablets, as their safety can’t be guaranteed.
• Regular blood pressure checks are recommended when using sildenafil long-term.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases.

Storage Condition	Details	Notes
Temperature	Keep below 30°C (86°F)	Avoid excessive heat
Light	Keep away from direct sunlight	Protect from UV rays
Humidity	Store in dry place	Prevent moisture from degrading the tablet
Out of reach	Keep out of children's reach	Safety precaution

If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Sildenafil (Revatio) will not be safe for you to take. Take nitrates, such as nitroglycerin or isosorbide mononitrate (Monoket) Take riociguat (Adempas) or other sGC stimulators You’ve probably heard of Viagra being commonly referred to as “the little blue pill”, and its distinctive blue colour is synonymous with the treatment of erectile dysfunction (ED). Sildenafil, the active ingredient in Viagra, is manufactured in a variety of colours, but most commonly in either blue or white. But does the colour and shape of your pill make a difference in the effectiveness of the treatment? When Viagra was first approved as a treatment for ED in 1998, it was marketed as “the little blue pill”.

• Sildenafil tablets are classified as phosphodiesterase inhibitors.
• White sildenafil tablets are available by prescription only.
• They should not be used with nitrates due to risk of dangerous drops in blood pressure.
• Certain medications may interact with sildenafil, including antibiotics and antifungals.
• The tablets are designed to last approximately 4-6 hours.
• Overuse can lead to adverse effects like dizziness or vision changes.
• Sildenafil helps men with erectile dysfunction achieve and maintain erections.
• The medicine is not an aphrodisiac and requires sexual stimulation.
• The tablets should be stored in a cool, dry place away from children.
• Beware of counterfeit sildenafil tablets sold online.
• Always verify the legitimacy of the medication before use.

The small, blue, diamond-shaped pill was patented by Viagra, meaning that both its appearance and active ingredient were exclusive to Viagra and couldn’t be copied by other manufacturers. After Pfizer’s patent for Viagra expired in 2013, sildenafil (the active ingredient in Viagra) was made more widely available for manufacturing by other companies. Nowadays, many manufacturers continue to make sildenafil as a blue-coloured pill, but it also comes in a variety of other shapes and colours, and is sometimes manufactured as a white pill. This is commonplace, and, as with many types of generic medication, you may find that the appearance of your pills sometimes changes each time you order them.